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The Gut-Brain Axis: How Stress Affects Digestive Health

IBS, mind-gut axis, digestive health, gi plano, gi frisco, gi dallas, gi mckinney, gi allen, gi the colony, gi prosper, gastroenterology plano, gastroenteroogy frisco, gastroenterology dallas

As a gastroenterologist, I often see firsthand the toll that stress can take on the gastrointestinal (GI) system. The brain and the gut have a very intimate relationship known as the gut-brain axis. When we experience chronic stress or difficult emotions, it can throw off the normal balance of digestive function, leading to common problems like irritable bowel syndrome (IBS), ulcer-type symptoms, and dyspepsia. In this article, I'll explain the science behind the mind-gut interaction and offer stress management tips to improve gut health.

The Mind-Gut Connection

The gastrointestinal tract is often called the "second brain" due to the 500 million neurons found in the enteric nervous system. This ‘little brain’ in the gut communicates back and forth with the big brain via the vagus nerve, hormones, and inflammatory cytokines [1].

When we perceive psychological or emotional stress, the hypothalamic-pituitary-adrenal (HPA) axis triggers the release of cortisol and other stress hormones. These hormones influence gut function and integrity. Cortisol increases gastric acid secretion and gut permeability (often referred to as "leaky gut"), allowing substances to pass into the bloodstream that normally wouldn't [2].

Stress disrupts the normal gut microbiome balance, decreasing beneficial bacteria like Lactobacillus. It also increases immune system activity which promotes inflammation in the GI tract [3]. This cascade of events from stress can manifest in a variety of digestive complaints:

  • Altered bowel habits (constipation, diarrhea, urgency)

  • Nausea, gas, or bloating

  • Abdominal discomfort or pain

  • Heartburn/reflux symptoms

Managing Stress for Gut Health

The good news is we have the power to manage our stress response through simple lifestyle techniques:

  • Deep breathing - Taking slow, diaphragmatic breaths stimulates the vagus nerve and reduces cortisol. Do this for 5 minutes, 2-3x daily.

  • Exercise - Physical activity releases endorphins, improves mood, and reduces inflammation. Aim for 30 minutes of exercise most days.

  • Relaxation practices - Meditation, yoga, and visualization prompts the relaxation response, lowering blood pressure and stress hormone levels.

  • Get enough sleep - Good sleep is vital for mental health, immune function, and gut microbial balance. Adults should get 7-9 hours per night. Not always so easy to do in our busy lives!

  • Healthy diet - Avoid eating to much of inflammatory foods like fried foods, processed carbs, and alcohol. Focus on anti-inflammatory foods like fatty fish, leafy greens, and colorful produce.

  • Social connection - Loneliness elevates cortisol. Spend time with supportive friends and family to buffer stress.

  • Cognitive behavioral therapy (CBT) - CBT can be a helpful tool for treatment of stress that helps identify distorted thought patterns that fuel anxiety and depression. A therapist can teach valuable coping techniques.

Supplements like probiotics, zinc, omega-3s, and adaptogens like ashwagandha may also help lower cortisol and balance the HPA axis. Identify your main life stressors and practice relaxation daily to counteract that pressure. Even simple measures like listening to music, taking a 10 minute timeout, or journaling your thoughts can induce the relaxation response.

The intimate connection between the brain and the gut has profound implications for our health. Chronic stress and difficult emotions can manifest physically in the form of gastrointestinal symptoms. At the same time, intestinal inflammation and an imbalanced microbiome can impact mood and mental health. Healing the gut and calming the mind go hand-in-hand.

Incorporate stress management along with a gut-healthy diet and lifestyle for optimal digestive wellness. The brain and the gut are intrinsically connected. When we support mental health and resilient stress coping, the gastrointestinal system is better able to keep digestion running smoothly.

Lifestyle measures like a gut-healthy diet, stress management techniques, regular exercise, and sufficient sleep all support gut and brain health. Certain medications, supplements, and alternative therapies may also be helpful depending on the individual. If you're struggling with unresolved digestive issues related to the mind-gut interaction, consider seeking expert care. Plano Gastroenterologist and Dallas Gastroenterologists like Dr. Stuart Akerman specialize in treating gastrointestinal disorders. Psychological care with Psychologists, Therapists, Yoga, and Alternative and Complementary Practitioners may all be components of a well-rounded plan of care. With comprehensive testing, an individualized treatment plan, and compassionate care, you can find relief. Your digestive wellbeing and mental health are too important to ignore.


1. Carabotti, M., Scirocco, A., Maselli, M. A., & Severi, C. (2015). The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology: quarterly publication of the Hellenic Society of Gastroenterology, 28(2), 203.

2. Konturek, P. C., Brzozowski, T., & Konturek, S. J. (2011). Stress and the gut: pathophysiology, clinical consequences, diagnostic approach and treatment options. Journal of physiology and pharmacology, 62(6), 591-599.

3. Moloney, R. D., Johnson, A. C., O’Mahony, S. M., Dinan, T. G., Greenwood-Van Meerveld, B., & Cryan, J. F. (2016). Stress and the microbiota-gut-brain axis: relevance to irritable bowel syndrome. CNS neuroscience & therapeutics, 22(2), 102-117.

4. Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. (2015). Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers. Psychopharmacology, 232(10), 1793-1801.

5. Slyepchenko, A., Maes, M., Jacka, F. N., Köhler, C. A., Barichello, T., McIntyre, R. S., ... & Carvalho, A. F. (2017). Gut microbiota, bacterial translocation, and interactions with diet: pathophysiological links between major depressive disorder and non-communicable medical comorbidities. Psychotherapy and psychosomatics, 86(1), 31-46.


DISCLAIMER: Please note that this blog is intended for Informational Use only and is not intended to replace personal evaluation and treatment by a medical provider. The information provided on this website is not intended as a substitute for medical advice or treatment. Please consult your doctor for any information related to your personal care.


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